Microneedling is a powerful skin rejuvenation method that uses ultra-fine needles to create controlled micro-injuries in the skin.
This process stimulates your body’s natural production of collagen and elastin, resulting in firmer, smoother, and more radiant skin texture. Whether you’re dealing with acne scars, enlarged pores, or early signs of aging, microneedling offers proven benefits for visible transformation.
The right serums make all the difference when paired with microneedling. Applying a serum specifically formulated for post-microneedling care can:
- Enhance absorption up to 300%, delivering active ingredients deep into freshly opened micro-channels
- Speed up healing by supporting skin barrier recovery
- Amplify hydration and nourishment, reducing redness and downtime
Not every serum fits this role. The best serum for microneedling is one that calms irritation, deeply hydrates, and supports the renewal process without introducing harsh or reactive ingredients.
One standout option is the Bradceuticals Gold Mesenchymal Stem Cell Growth Factor Serum. This formula uses advanced stem cell technology to provide a post-microneedling glow—promoting rapid recovery, boosting collagen synthesis, and visibly enhancing radiance.
Unlocking the full benefits of microneedling starts with understanding how these serums work in harmony with your skin’s natural healing process. To optimize results further, consider following a specific microneedling protocol that incorporates growth factors for enhanced effectiveness.
Understanding Microneedling and Serum Compatibility
Microneedling works by creating controlled micro-injuries in the skin, prompting collagen and elastin production for visible rejuvenation. The choice of serum for derma roller or derma pen treatments plays a critical role in both immediate recovery and long-term results. When these micro-channels are open, your skin absorbs topical ingredients much more efficiently—making the selection of microneedling serum ingredients more important than ever.
Professional vs. At-Home Microneedling Tools:
- Derma Pen: Used by professionals, offers precise needle depth adjustment and enhanced control for targeted treatments.
- Derma Roller: A popular at-home microneedling device, less customizable yet effective for boosting product absorption and encouraging gentle collagen formation.
Not every serum is safe post-procedure. Immediately after microneedling, avoid:
- Vitamin C
- Retinoids
- Exfoliating acids (AHAs/BHAs)
- Benzoyl peroxide
These ingredients can irritate sensitized skin or disrupt healing. Instead, focus on serums that are gentle, hydrating, and soothing:
- Hyaluronic acid
- Peptides
- Growth factors
Bradceuticals Gold Mesenchymal Stem Cell Growth Factor Serum fits this profile. It delivers advanced hydration with growth factors to speed recovery and impart a post-microneedling glow without triggering irritation.
Selecting the best derma-compatible serums ensures your skin receives maximum benefits from both professional treatments and at-home microneedling routines.
Best Types of Serums to Use with Microneedling
Selecting the best serum for microneedling depends on your skin’s needs and the type of results you want to achieve. The right formula can transform your post-microneedling experience, amplifying hydration, soothing sensitivity, and driving visible improvements in skin texture and tone. Here are the best serums to use with microneedling:
1. Hyaluronic Acid Serums
Deep hydration is critical after microneedling. Hyaluronic acid draws moisture into the skin, helping it appear plumper and feel more comfortable as it heals. A standout option is Cosmedica Pure Hyaluronic Acid Serum, often cited as the best hyaluronic acid serum for microneedling due to its clean, single-ingredient formula.
2. Peptide Serums
Peptides send signals that boost collagen production, targeting fine lines and loss of firmness. This makes them a strong candidate for anyone seeking anti-aging benefits. Olay Collagen Peptide 24 Serum delivers proven results for skin firmness and improved elasticity.
3. Growth Factor Serums (EGF)
Epidermal growth factors accelerate wound recovery, reduce inflammation, and promote new elastin synthesis—key elements for optimal healing after microneedling. Diaminy Aesthetics EGF Serum is formulated to actively support these processes.
4. Stem Cell Serums
Plant or human-derived stem cell extracts supply growth factors and vitamins like B5, enhancing collagen production and supporting rapid skin repair. These serums are especially beneficial after intense treatments. To maximize the benefits of these serums, here’s a guide on how to enhance your microneedling routine with the best stem cell serum.
5. Niacinamide + Zinc Serums
Niacinamide helps regulate oil production while zinc calms inflammation—properties valued by those with acne-prone or sensitive skin. The Ordinary Niacinamide 10% + Zinc 1% stands out among the best serums after microneedling for oil control without irritation.
Choosing from these categories ensures you’re using the best serums to use with microneedling—each option supports different aspects of healing, hydration, and visible rejuvenation post-treatment.
Popular Microneedling Serums in 2024 You Should Know About
More and more brands are now offering specialized serums that are specifically designed to enhance the effects of microneedling procedures. Here are some of the top derma serum brands and popular serums for microneedling that are gaining popularity this year:
1. Bradceuticals Gold Mesenchymal Serum
Packed with mesenchymal stem cell-derived growth factors, this serum accelerates skin rejuvenation and healing post-microneedling. Users report a noticeable “glow” and rapid reduction in redness—making it a top contender for those seeking the best serum after microneedling.
2. CALECIM Professional Serum
Stem cell-based proteins sourced from ethically derived umbilical cord lining boost regeneration and soothe irritation. This formula is favored by professionals aiming for visible firmness and repair without heavy texture.
3. Dr Pen Serum
Formulated specifically for compatibility with derma pen devices, this serum glides effortlessly during treatments, maximizing absorption and minimizing friction. The lightweight consistency suits all skin types.
4. Medicube One Day Exosome Shot 2000
Features exosome-coated spicules that deliver regenerative ingredients deep into micro-channels, supporting faster recovery and enhanced skin resilience.
5. COSNORI PDRN-Shot 675
Harnesses salmon DNA (PDRN) to accelerate tissue repair, stimulate collagen production, and promote evenness in tone—making it one of the best serums for microneedling targeting post-acne marks or textural irregularities.
6. VT COSMETICS CICA Reedle Shot 100
Soothes sensitive complexions using Centella Asiatica extract while also reducing visible inflammation after procedures. A gentle option recommended for first-timers or those with reactive skin.
7. Yuree Cosyuree Spicule Collagen Serum
Supports effective collagen synthesis through innovative spicule technology, ensuring firmer texture and visible plumping after each session.
Choosing from these options allows you to select the best serum for your microneedling routine based on your desired results—whether you prioritize hydration, calming effects, or advanced anti-aging support.
How to Apply Serums Correctly After Microneedling for Optimal Results
Timing is critical with microneedling post-care serums. The micro-channels created by needles remain open for a short window—usually five minutes or less. Applying your chosen serum during this period allows active ingredients to penetrate deeper, amplifying the treatment’s benefits. Missing this window means diminished absorption and slower results.
Step-by-Step Guide for Serum Application:
- Clean Hands, Clean Tools: Wash hands thoroughly and ensure all tools used are sanitized.
- Gentle Cleansing: Use a mild, hydrating cleanser on your skin, avoiding harsh exfoliants or actives.
- Pat Dry: Gently pat the skin dry with a sterile towel.
- Immediate Serum Application: Dispense your serum (such as Bradceuticals Gold Mesenchymal Serum) onto fingertips and apply an even layer across treated areas within five minutes of finishing microneedling or derma rolling.
- No Rubbing: Lightly press the serum into the skin—avoid rubbing or massaging aggressively.
- Repeat Hydration: Reapply a hydrating serum as needed throughout the day to keep the skin moist and support healing.
Hydration is your best friend after microneedling. A sterile hyaluronic acid serum locks in moisture and soothes sensitivity.
Shielding your freshly treated skin from environmental stressors is equally important. Use only fragrance-free, non-comedogenic moisturizers and avoid direct sunlight until the barrier feels fully restored. Broad-spectrum sunscreen becomes essential from day two onward to prevent unwanted pigmentation during recovery.
Post-Microneedling Skincare Tips and Precautions
1. Sun Protection
After microneedling, newly exposed skin is highly sensitive and vulnerable to UV damage. Applying a broad-spectrum sunscreen (SPF 30 or higher) every morning shields your skin from pigmentation issues and supports even skin rejuvenation after microneedling.
2. Avoid Irritants
Skip exfoliants, acids, retinoids, or benzoyl peroxide until your skin has fully healed. These ingredients can trigger irritation, redness, or delayed recovery.
3. Antioxidant Care
Reserve potent antioxidants like vitamin C for later—only incorporate them once all redness and sensitivity have subsided. This step helps fortify long-term results by defending against oxidative stress and supporting collagen renewal.
Paying attention to these post-treatment details helps maintain smooth progress as your skin recovers and transforms.
Conclusion
Choosing the best serum for microneedling or the best serum for derma roller starts with understanding your skin’s needs—whether you want deep hydration, anti-aging support, or acne control. Always match your serum to your concerns:
- Hydration: Look for pure hyaluronic acid formulas.
- Anti-aging: Opt for peptides or growth factor serums.
- Acne-prone: Niacinamide and zinc blends are reliable.
Stick to a consistent post-care routine: apply your chosen serum promptly post-treatment, keep skin protected from the sun, and avoid harsh ingredients during recovery. Consistency leads to visible, healthy radiance that lasts.
Reference articles
https://diaminyaesthetics.com/blogs/news/best-serums-for-at-home-microneedling
https://facemedstore.com/best-serums-for-at-home-microneedling
https://www.allure.com/story/microneedling-serums
https://us.drpen.co/blogs/news/the-best-serums-to-use-with-microneedling
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About Bradceuticals : Thuy Myers is the founder of Bradceuticals which manufactures and distributes skin care and hair regrowth serums that use growth factors from human stem cells as the catalyst for regeneration. When she is not busy running the business and maintaining blogs, she is continuing her practice as a semiconductor engineer and occasionally teaches college engineering. In her free time, she enjoys the beach, working out at the gym and hanging out with her kiddo Brad.