You microneedled without growth factors and called the results good. They were not good. They were a fraction of what your skin was capable of building in that session. Every channel your device created reached fibroblasts that were waiting for biological instruction — and received nothing but hyaluronic acid that absorbs through intact skin every morning without help. A randomized controlled trial confirmed that microneedling with growth factor produced significant improvements after one session — results the control group needed four sessions to approach (PMC7716740).
Four sessions of pain. Four sessions of downtime. Four sessions of expense. Or one — with the right molecule through the right channels at the right time. Bradceuticals Gold Mesenchymal Stem Cell Growth Factor Serum delivers the complete bone marrow MSC secretome through channels your device creates — applied to damp skin within the first few minutes after your final pass. Here is what microneedling with growth factor actually produces when the protocol is complete.
Result 1: One Session Matches Four
The clinical trial was definitive. Microneedling with growth factor produced improvements in skin texture, wrinkle depth, and overall rejuvenation after a single session that the control group — microneedling without growth factors — required four sessions to approach (PMC7716740). Growth factors activate the PI3K/AKT and ERK/MAPK pathways commanding collagen synthesis (PMC10333026). Without them, your device creates channels and your body heals them. With them, your device creates channels and your body builds structural collagen through them.
Result 2: Collagen That Lasts Five to Seven Years
Microneedling with growth factor does not produce temporary improvement. New collagen fibers deposited through growth factor-enhanced channels persist five to seven years (PMC11993440). A 24-week trial demonstrated biopsy-confirmed increases in collagen, elastin, AND decorin — with participants perceiving themselves six years younger (PMC9823186). This is not skincare. This is structural engineering for your face.
Result 3: Construction AND Demolition Prevention
Microneedling with growth factor does two jobs simultaneously that no other serum category can. EGF inhibits inflammatory cytokines IL-1alpha, IL-8, and TNF-alpha (PMC10333026). MSC exosomes restore TIMP-1 and inhibit MMP-1 through -9 while enhancing collagen types I through V (PMC12395928). Building new collagen while MMP enzymes destroy existing collagen produces zero net gain. Microneedling with growth factor delivers both sides — instruction to build AND protection from demolition.
Result 4: Faster Recovery
EGF does not just build collagen — it calms the inflammatory response that makes the first 48 hours uncomfortable. Microneedling with growth factor shortens visible redness and reduces the tight, stinging sensation that makes most people dread the recovery phase. The anti-inflammatory properties of growth factors make microneedling with growth factor among the most comfortable post-procedure experiences available.
Result 5: Daily Results Between Sessions
Microneedling with growth factor is not a one-day protocol. The clinical trial maintained twice-daily growth factor application between monthly sessions (PMC7716740). Visible improvement confirmed from conditioned media on intact skin at just 4 weeks (PMC6002314). Good on intact skin daily. Dramatically better through channels. Microneedling with growth factor works both ways — channels amplify what daily application already delivers.
The Complete Microneedling With Growth Factor Routine
Here is every product you need, in exact order, with links:
Step 1 — Glide serum (during needling): Choose one:
- Dp Dermaceuticals HYLA ACTIVE — professional standard, HylaFuse technology
- LUMNi Hyaluronic Acid Microneedling Serum — sterile vials, clinical purity
- MD Needle Pen Hyaluronic Acid Serum — device-tested, accessible price
Step 2 — Growth factor serum (minutes 0-5 after final pass):
- Bradceuticals Gold Mesenchymal Stem Cell Growth Factor Serum — complete bone marrow MSC secretome, applied to damp skin
Step 3 — Hydration layer (minutes 10-15):
- Cosmedica Pure Hyaluronic Acid Serum — fragrance-free, under $15
Step 4 — Barrier repair (day 2+):
- The Ordinary Niacinamide 10% + Zinc 1% — strengthens barrier, reduces redness
Step 5 — Seal (minutes 15-20):
- CeraVe Moisturizing Cream — ceramides, MVE technology, locks everything in
Step 6 — Protection (morning after):
- Mineral sunscreen SPF 30+ — protects new collagen from UV-triggered MMP activation
Between sessions: Continue Bradceuticals twice daily on intact skin. Schedule next microneedling with growth factor session in 4-6 weeks.
Essential: Patch test every product before first session. Apply to a small area behind the ear after a single pass. Wait 24-48 hours.
Frequently Asked Questions
Does microneedling with growth factor really work? Yes — a randomized controlled trial confirmed one session with growth factors matched four without (PMC7716740). Biopsy-confirmed collagen at 24 weeks (PMC9823186).
Is microneedling with growth factor safe at home? Yes — home dermarollers under 0.5mm are validated for transdermal delivery (PMC11993440). Same protocol, same products.
How does microneedling with growth factor compare to PRP? A 2025 trial confirmed MSC exosomes matched PRP with biopsy-confirmed Collagen I increases (PMC12104007). Topical conditioned media delivers comparable results without blood draw.
How often should I do microneedling with growth factor? Monthly sessions with twice-daily growth factor serum between sessions. The clinical trial maintained this protocol (PMC7716740).
References
- Merati M, et al. An Assessment of Microneedling with Topical Growth Factors. J Clin Aesthet Dermatol. 2020;13(11):22-27. (PMC7716740)
- Shin SH, et al. The use of epidermal growth factor in dermatological practice. Int Wound J. 2023;20(6):2414-2423. (PMC10333026)
- Tehrani L, et al. Physiological Mechanisms and Therapeutic Applications of Microneedling. Cureus. 2025;17(3):e80510. (PMC11993440)
- Naughton GK, et al. Targeting Multiple Hallmarks of Skin Aging. Dermatol Ther. 2023;13(1):169-186. (PMC9823186)
- Gui Q, et al. Extracellular vesicles derived from MSCs to treat skin aging. Precis Clin Med. 2024;7(1):pbae004. (PMC12395928)
- Kim YJ, et al. Anti-aging Properties of EPC-CM. Dermatol Ther (Heidelb). 2018;8(2):261-273. (PMC6002314)
- Estupiñan B, et al. ASC Exosomes vs PRP for Photoaged Facial Skin. J Cosmet Dermatol. 2025;24(5):e70208. (PMC12104007)
Disclaimer: This article is for informational purposes only and does not constitute medical advice. The products discussed are cosmetic products and are not intended to diagnose, treat, cure, or prevent any disease. Individuals with any active skin condition, pre-existing medical condition, or those currently under the care of a physician or specialist should consult their healthcare provider before beginning any new skincare regimen. Always perform a patch test before using any new skincare product. Consult a qualified healthcare provider before beginning any microneedling protocol. Individual results may vary.
Last Reviewed: April 2026
About Bradceuticals : Thuy Myers is the founder of Bradceuticals which manufactures and distributes skin care and hair regrowth serums that use growth factors from human stem cells as the catalyst for regeneration. When she is not busy running the business and maintaining blogs, she is continuing her practice as a semiconductor engineer and occasionally teaches college engineering. In her free time, she enjoys visiting the beach with her MUCH better half, working out at the gym, and hanging out with her kiddo.