Microneedling is a popular skincare treatment that involves using tiny needles to create micro-wounds in the skin.

This process stimulates collagen production and improves skin texture, reducing the appearance of fine lines, wrinkles, and scars. To get the most out of microneedling, it’s important to use the right serum during and after the treatment.
Using an appropriate serum can greatly improve your results by:
- Making the treatment more comfortable
- Improving device glide
- Increasing product absorption by up to 300%
In this article, we’ll show you how to choose the best serums for microneedling. We’ll discuss different types of serums, their benefits, and how to apply them correctly. For instance, Bradceuticals Gold Mesenchymal Stem Cell Growth Factor Serum, which is part of our microneedling with stem cells protocol, is highly recommended for achieving a radiant post-microneedling glow.
These serums contain proteins that promote cell growth and repair, making them highly effective in reducing wrinkles, fine lines, and scars when used during the microneedling protocol phase.
Understanding Microneedling and Its Interaction with Serums
Microneedling involves the use of a derma roller or derma pen to create micro-wounds in the skin. These tiny punctures stimulate collagen production and improve skin texture, reducing fine lines, wrinkles, hyperpigmentation, and scarring. The micro-wounds increase serum absorption by up to 300%, making it crucial to choose the right serum during and after treatment.
Serums play a vital role in enhancing the microneedling experience:
- Making the treatment more comfortable
- Improving device glide
- Maximizing treatment results through increased absorption
There are notable differences between professional and at-home microneedling regarding serum use. Professional treatments typically involve more advanced devices and potent serums tailored by dermatologists. At-home microneedling requires careful selection of gentle, non-reactive serums to avoid irritation.
One highly recommended product for post-microneedling is the Bradceuticals Gold Mesenchymal Stem Cell Growth Factor Serum. This serum promotes a radiant glow by supporting skin regeneration and healing, making it an excellent choice for enhancing post-treatment results.
By understanding how microneedling interacts with serums and selecting appropriate products, you can significantly improve your skincare outcomes.
What Types of Serums Are Safe to Use with Microneedling?
Choosing safe serums for microneedling is crucial to avoid adverse reactions and maximize benefits. Some serums, such as vitamin C brightening serum, retinol, and AHA/BHA acids, should be avoided immediately post-treatment due to their potential to cause irritation and sensitivity when applied through the micro-channels created by needling.
Important considerations when selecting serums:
- Gentle Formulations: Opt for gentle, non-reactive formulations free from fragrances or harsh ingredients. These are less likely to irritate sensitive skin post-microneedling.
- Patch Testing: Always conduct a patch test before full application. This helps identify any potential adverse reactions on a small area of skin.
- Consulting a Dermatologist: If unsure about the suitability of a serum, consulting with a dermatologist can provide personalized recommendations based on your skin type and concerns.
One highly recommended product is the Bradceuticals Gold Mesenchymal Stem Cell Growth Factor Serum. This serum is known for its soothing properties and ability to promote post-microneedling glow, making it an excellent choice for those looking to enhance their treatment outcomes safely.
By prioritizing gentle ingredients and professional advice, you can ensure the best possible results from your microneedling sessions while minimizing risks.
Best Serums to Use During and After Microneedling
When selecting the best serums for microneedling, hydration and skin barrier support are top priorities. The micro-channels created by needling allow actives to reach deeper layers of the skin, which means choosing a serum designed for safety, efficacy, and comfort is essential.
Hyaluronic Acid Serums
Hyaluronic acid is widely recognized as the gold standard when considering what serum to use with microneedling. Its unique ability to attract and retain up to 1,000 times its weight in water makes it a powerhouse for deep hydration.
Benefits of Hyaluronic Acid Serums
- Restores Moisture: Microneedling can temporarily disrupt the skin barrier, leading to dehydration. Hyaluronic acid serums help replenish lost moisture instantly, soothing tightness and keeping your complexion plump.
- Supports Repair: Hyaluronic acid aids in the repair of fine lines, wrinkles, and sun-induced damage by promoting optimal moisture levels throughout the healing process. Skin appears smoother and more resilient post-treatment.
- Non-Irritating Formula: Pure hyaluronic acid serums typically exclude fragrances, oils, or actives that could irritate sensitized skin. This makes them especially suitable for immediate post-microneedling application.
Recommended Products
- Cosmedica Pure Hyaluronic Acid Serum: Lightweight, fast-absorbing formula ideal for layering or standalone use after needling.
- Neutrogena Hydro Boost Hydrating Serum: A widely available option known for its gel-like texture and immediate hydrating effect.
Hydration remains the foundation of post-microneedling care—hyaluronic acid delivers this without risking irritation or clogging pores.
Moving beyond hydration-focused products opens the door to targeted treatments like peptides and growth factors that further amplify results from your device.
Peptides-Based Serums
Peptides-based serums are among the best serums for microneedling, known for their compatibility with this procedure. These serums are valued for their ability to:
- Stimulate Collagen Production: Peptides signal the skin to produce more collagen, essential for reducing muscle contraction lines that contribute to wrinkles and fine lines.
- Enhance Skin Firmness and Elasticity: By boosting collagen and elastin levels, peptides improve the skin’s structural integrity, resulting in a firmer and more resilient appearance.
When considering what serum to use with microneedling, peptide-based options like Drunk Elephant Protini Polypeptide Cream or The Ordinary “Buffet” Serum are excellent choices. They not only support anti-aging effects but also aid in overall skin repair, ensuring optimal results from your microneedling treatment.
Ceramide Serums
Ceramide serums are highly beneficial for microneedling due to their ability to restore the skin’s lipid barrier. This barrier is crucial for maintaining hydration, as it helps prevent moisture loss during the healing process. By fortifying the skin’s natural defenses, ceramides ensure that the skin remains hydrated and supple.
Key benefits of ceramide serums include:
- Restoration of the lipid barrier: Essential for keeping your skin plump and healthy post-treatment.
- Protection against moisture loss: Vital for speeding up recovery and ensuring that your skin heals efficiently.
Top recommended ceramide serums known for compatibility with microneedling procedures include:
- CeraVe Hydrating Hyaluronic Acid Serum: Integrates both hyaluronic acid and ceramides to deliver intense hydration.
- Dr. Jart+ Ceramidin Liquid: A lightweight serum that provides long-lasting moisture and strengthens the skin barrier.
When deciding what serum to use with microneedling, consider incorporating ceramides into your regimen for optimal hydration and faster recovery.
Epidermal Growth Factor (EGF) Serums
Epidermal Growth Factor (EGF) serums are highly recommended for microneedling due to their potent regenerative properties. These serums:
- Promote Cellular Regeneration: EGF stimulates the growth of new skin cells, accelerating the healing process and enhancing overall skin health.
- Boost Collagen/Elastin Synthesis: By increasing collagen and elastin production, EGF serums help reduce fine lines, wrinkles, and improve skin elasticity.
- Reduce Signs of Aging: Regular use can diminish hyperpigmentation and age spots while providing a more youthful appearance.
- Strengthen Skin Barrier Integrity: EGF fortifies the skin’s natural barrier, which is crucial after microneedling to protect against environmental factors.
Top recommended EGF serums include options like BioEffect EGF Serum and SkinMedica TNS Essential Serum, known for their compatibility with microneedling procedures. These products ensure enhanced absorption and efficacy post-treatment.
How to Properly Apply Serum When Using Microneedling Tools at Home?
Using serum with microneedling at home starts with timing. To maximize absorption, always apply your chosen serum within five minutes after finishing the treatment—this is when the micro-channels created by the device are most receptive.
Step-by-Step Serum Application After Microneedling:
- Cleanse Your Skin: Begin with a gentle cleanser to ensure your skin is free from debris and oils.
- Microneedle as Directed: Use your derma roller or derma pen according to instructions, focusing on even pressure and coverage.
- Apply Serum Promptly: Dispense a pea-sized amount of serum onto fingertips. Gently press or pat into treated areas; avoid rubbing, which may irritate sensitized skin.
- Let It Absorb: Allow the serum to fully sink in before applying any moisturizer or sunscreen.
Less is more. Overuse of serums can lead to irritation, redness, or breakouts. Stick to recommended amounts and watch for any adverse reactions.
Differences Between Derma Rollers and Derma Pens:
- Derma rollers create slightly larger channels across broader areas; thicker serums like hyaluronic acid are ideal as they glide smoothly.
- Derma pens offer precision targeting; lighter-textured serums can penetrate efficiently without pooling.
Common questions include “what serum should I use after microneedling?” and “what serum to use after dermarolling?” Always prioritize hydrating, fragrance-free formulas specifically designed for post-procedure skin. Peptides, ceramides, and EGF serums are well-tolerated choices for both devices.
Common Mistakes to Avoid When Using Serums with Microneedling
Selecting the right serum for microneedling is only part of the process—knowing what not to do can be equally important for safe and effective results. Several common errors can compromise skin health and undermine the benefits of your treatment.
Serums to Avoid After Dermarolling
- Acidic or highly active serums: Vitamin C, retinol, AHA/BHA acids, and other strong actives should never be applied right after microneedling. These ingredients can penetrate too deeply through micro-channels, triggering burning, redness, or even chemical burns.
- Fragranced or heavily preserved products: Fragrances and unnecessary preservatives are more likely to irritate freshly needled skin.
Skipping Patch Tests
- Always patch test any new serum before full-face application. Even if a product claims to be gentle, each individual’s skin can react differently post-microneedling.
- Ignoring signs of irritation—such as itching, swelling, or prolonged redness—puts you at risk for longer-term skin issues.
Using Too Many Products at Once
- Layering multiple potent serums immediately after treatment overwhelms the skin barrier. Stick to a single, targeted formula that answers the question: what serum to use with microneedling?
- Overloading can lead to congestion, delayed healing, or increased sensitivity during your recovery window.
A careful approach ensures optimal healing and maximizes visible improvements from each session.
Recommended Products & Brands for Microneedling Serums
Choosing the right serum is crucial for maximizing the benefits of microneedling. Here are some highly recommended products and brands:
- Bradceuticals Gold Mesenchymal Stem Cell Growth Factor Serum: Known for its post-microneedling glow, this serum contains growth factors that boost cellular regeneration and collagen production.
- Cosmedica Pure Hyaluronic Acid Serum: This serum is praised for its hydrating properties, making it an excellent choice to replenish moisture lost during needling and support wrinkle repair.
- Neutrogena Hydro Boost Hydrating Serum: Infused with hyaluronic acid, this serum helps maintain skin hydration and aids in healing sun damage, making it ideal for post-microneedling care.
- The Ordinary “Buffet” Multi-Technology Peptide Serum: A peptide-based formula that stimulates collagen production, enhances skin firmness, and reduces muscle contraction lines for anti-aging effects.
- Dr. Jart+ Ceramidin Liquid: This ceramide-rich serum restores the skin’s lipid barrier and maintains hydration during the healing process, speeding up recovery by protecting against moisture loss.
- Bioeffect EGF Serum: Contains Epidermal Growth Factor (EGF) to promote cellular regeneration, boost collagen/elastin synthesis, reduce signs of aging such as wrinkles and hyperpigmentation while strengthening skin barrier integrity.
These products are formulated to maximize the benefits of microneedling while minimizing potential irritation or adverse reactions.
Conclusion
Choosing the right serum for microneedling can significantly enhance your treatment results. Microneedling creates micro-channels in the skin, allowing serums to be absorbed up to 300% more effectively. Using the appropriate serum not only maximizes these benefits but also ensures a comfortable experience and optimal healing.
Key takeaways when deciding what serum to use with microneedling include:
- Avoid serums with vitamin C, retinoids, or acids immediately post-treatment due to their potential for irritation.
- Opt for gentle, non-reactive formulations free from harsh ingredients and fragrances.
- Consider serums with hyaluronic acid, peptides, ceramides, or epidermal growth factor (EGF) for their hydrating, anti-aging, and healing properties.
For best results:
- Apply the serum within five minutes after microneedling.
- Conduct a patch test before full application.
- Consult a dermatologist if unsure about a product’s suitability.
Using the right serum during and after microneedling can transform your skincare routine, leading to improved skin texture, reduced wrinkles and scars, and a youthful glow. Always prioritize safety and efficacy by choosing well-formulated products tailored to your skin’s needs.
Reference articles
https://diaminyaesthetics.com/blogs/news/best-serums-for-at-home-microneedling
https://facemedstore.com/best-serums-for-at-home-microneedling
https://www.healthline.com/health/beauty-skin-care/microneedling-at-home
https://caci.co.nz/blogs/skin-101/skin-101-how-to-use-a-derma-roller
https://drpen.com.au/blogs/news/the-best-serums-to-use-with-microneedling
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About Bradceuticals : Thuy Myers is the founder of Bradceuticals which manufactures and distributes skin care and hair regrowth serums that use growth factors from human stem cells as the catalyst for regeneration. When she is not busy running the business and maintaining blogs, she is continuing her practice as a semiconductor engineer and occasionally teaches college engineering. In her free time, she enjoys the beach, working out at the gym and hanging out with her kiddo Brad.