Microneedling has become very popular among skincare lovers and professionals because it can help with various skin issues like fine lines, acne scars, uneven texture, and sagging skin.

During the procedure, tiny needles are used to create small injuries on the skin, which triggers the production of collagen and promotes natural rejuvenation.
Using the right serums in combination with microneedling is essential for maximizing these benefits. After the treatment, enhanced absorption allows the active ingredients in the serums to penetrate deeper into the skin, resulting in increased hydration, healing, and visible improvements. However, not all serums are suitable for this purpose; understanding which serum to use during microneedling can make a significant difference between achieving a radiant complexion or experiencing unwanted irritation.
In this article, we will answer common questions such as what serums are recommended for microneedling and which serum should be applied after microneedling. We will also take an in-depth look at powerful formulations like Bradceuticals Gold Mesenchymal Stem Cell Growth Factor Serum that can enhance post-microneedling results. This particular serum belongs to a wider range of anti-aging serums that have gained popularity in the skincare industry due to their effectiveness in reducing fine lines and wrinkles without invasive procedures. For more information on this topic, please refer to our guide on how to choose the best affordable growth factor serum.
Additionally, we will provide specific recommendations for serums that work well with microneedling—customized to optimize the outcome of your upcoming treatment session.
Understanding Microneedling and the Role of Serums
Microneedling is a cosmetic treatment that involves using tiny needles to create controlled micro-injuries in the skin. This process stimulates collagen and elastin production, leading to improved skin texture, reduced acne scars, fine lines, wrinkles, and a firmer, more youthful complexion.
Different Tools Used in Microneedling
There are different tools used in microneedling:
- Derma Roller: A handheld device with a rolling drum covered in tiny needles. Ideal for at-home microneedling sessions.
- Derma Pen: A pen-like device with oscillating needles. Known for its precision and effectiveness in professional settings.
The Importance of Serums in Microneedling
Using serums during the microneedling procedure is crucial for optimal results. The micro-injuries created by microneedling make the skin more receptive to active ingredients in serums, enhancing their absorption by up to 300%. This increased absorption boosts hydration, healing, and collagen production.
Popular Serums for Microneedling
It’s important to choose the right serums for use with microneedling. Some popular options include:
- Bradceuticals Gold Mesenchymal Stem Cell Growth Factor Serum: Known for its post-microneedling glow and enhancing the microneedling experience significantly.
- Hyaluronic Acid (HA) Serums: Provides intense hydration and plumps the skin.
- Peptide-Infused Serums: Stimulates collagen synthesis.
- Ceramide-Rich Serums: Strengthens the skin barrier.
- Epidermal Growth Factor (EGF) Serums: Accelerates healing.
Selecting the appropriate serum can significantly enhance the benefits of microneedling.
1. Hyaluronic Acid (HA) Serums: The Hydration Powerhouse
Hyaluronic acid is a key ingredient in post-microneedling skincare. It has the incredible ability to hold up to 1,000 times its weight in water, making it perfect for drawing moisture deep into the skin. This is especially important after microneedling sessions when the skin is vulnerable and thirsty for hydration.
Key Benefits of Hyaluronic Acid Serums:
- Intense Hydration: Instantly replenishes the skin’s moisture reserves, supporting faster recovery.
- Plumping Effect: Visibly smooths and plumps fine lines and wrinkles by boosting skin elasticity.
- Enhanced Glow: Promotes a dewy, luminous appearance that’s often described as the coveted “post-microneedling glow.”
- Gentle on Skin: Non-irritating and suitable for all skin types—including sensitive and acne-prone—making it a safe choice during the healing window.
One standout option is the Bradceuticals Gold Mesenchymal Stem Cell Growth Factor Serum, which combines pharmaceutical-grade hyaluronic acid with advanced growth factors. This serum not only provides intense hydration but also uses stem cell technology to enhance rejuvenation. Many users have reported improved texture, faster healing, and a radiant finish when using this serum immediately after microneedling.
The combination of intense moisture delivery and barrier support makes HA serums an essential first layer immediately after your treatment.
Using hyaluronic acid with microneedling can greatly improve the recovery process by reducing dryness or tightness while also promoting long-lasting results.
2. Peptide-Infused Serums: Boosting Collagen Production
Peptides are essential for keeping our skin looking young because they help produce collagen. Collagen is a protein that gives our skin firmness and elasticity. Peptides are short chains of amino acids that serve as the building blocks for proteins in our skin.
When combined with microneedling, peptide-infused serums can greatly improve the skin’s natural ability to heal and rejuvenate itself.
Benefits of Peptides in Microneedling
- Stimulating Collagen Production: Peptides send signals to the skin to produce more collagen, which is crucial for maintaining its structure and reducing fine lines and wrinkles.
- Improving Skin Texture: Regular use of peptide serums can result in smoother, firmer skin with better texture and tone.
- Boosting Skin Repair: Peptides help repair damaged cells, making them ideal for applying after microneedling to speed up healing.
Recommended Peptide Formulations
One standout product is the Bradceuticals Gold Mesenchymal Stem Cell Growth Factor Serum. This serum is specifically designed for post-microneedling glow, harnessing the power of peptides and stem cell growth factors to maximize collagen production and overall skin health.
Key Features:
- Contains mesenchymal stem cell growth factors that work synergistically with peptides.
- Enhances skin repair processes.
- Reduces visible signs of aging such as wrinkles and sagging.
Using peptide-infused serums like this one after microneedling ensures you get the most out of your treatment, promoting a firmer, more youthful-looking complexion.
3. Ceramide-Rich Serums: Strengthening the Skin Barrier
Microneedling temporarily disrupts the skin’s protective barrier, making it more susceptible to moisture loss and irritation. Ceramides play a crucial role in repairing and reinforcing this barrier post-treatment. These lipid molecules are naturally present in the skin’s outer layer, where they help retain hydration and shield against external stressors.
When you infuse your post-microneedling routine with ceramide-rich serums, you deliver targeted support for faster recovery and lasting comfort. Skin feels less tight, redness subsides quicker, and flakiness is kept at bay. Ceramides also help lock in moisture delivered by other hydrating ingredients, maximizing results from your session.
Popular options include:
- Bradceuticals Gold Mesenchymal Stem Cell Growth Factor Serum: This formula stands out for its combination of ceramides and growth factors, providing both deep hydration and advanced repair for a visible post-microneedling glow.
- Dr. Jart+ Ceramidin Liquid: Known for its lightweight consistency and concentrated ceramide content, this serum supports barrier restoration without heaviness or clogging pores.
- CeraVe Hydrating Hyaluronic Acid Serum: Blending ceramides with hyaluronic acid for dual-action smoothing, this option works well for sensitive or compromised skin types.
“Using a ceramide-based serum after microneedling is like putting up a protective shield while your skin does its best renewal work behind the scenes.”
Selecting serums that prioritize ceramides keeps newly treated skin resilient—ready to benefit from deeper ingredients in each subsequent step.
4. Epidermal Growth Factor (EGF) Serums: Accelerating Healing
Epidermal growth factors (EGF) are crucial in the healing process after microneedling, promoting faster cell rejuvenation and repair. These proteins are essential for stimulating collagen and elastin production, which maintain the skin’s structure and youthful appearance.
How EGF Serums Work
EGF serums function by attaching to specific receptors on skin cells, initiating a series of biochemical reactions that speed up wound healing and tissue regeneration. This not only shortens recovery time but also improves the overall effectiveness of microneedling treatments by enhancing skin texture and minimizing scars and wrinkles.
Recommended EGF Formulations
Here are some recommended EGF formulations that can be beneficial for your skin:
- Bioeffect EGF Serum: Known for its purity and efficacy, this serum utilizes barley-derived EGF to significantly boost collagen production, improve hydration, and reduce signs of aging.
- SkinMedica TNS Essential Serum: Combines growth factors with antioxidants and peptides for comprehensive skin rejuvenation. This dual-chamber serum targets multiple skin concerns simultaneously.
- AQ Skin Solutions Active Serum: Rich in human fibroblast conditioned media, this serum is designed to enhance cellular repair processes, making it ideal for post-microneedling use.
Incorporating EGF serums into your microneedling routine can significantly enhance healing outcomes, leaving your skin looking revitalized and more resilient.
5. Niacinamide + Zinc Formulations: Soothing Inflammation
Niacinamide + zinc formulations stand out for their ability to calm the skin after microneedling. When choosing what serum to use for microneedling, these combinations offer targeted relief from redness and help reduce post-treatment inflammation.
Key benefits of niacinamide + zinc serums post-microneedling:
- Redness Reduction: Niacinamide is well-known for its anti-inflammatory properties, working quickly to minimize visible redness and soothe the skin.
- Oil Regulation: Zinc helps balance oil production, making these serums especially helpful if you have oily or blemish-prone skin.
- Barrier Support: Niacinamide strengthens the skin’s natural barrier, supporting recovery and preventing dehydration.
- Even Skin Tone: Consistent use can fade dark spots and improve uneven pigmentation frequently aggravated by invasive treatments.
Ideal options typically contain 5–10% niacinamide paired with a small percentage of zinc (around 1%), offering a lightweight texture that absorbs easily without clogging pores. These formulations work well layered after hydrating serums, preparing your skin to heal calmly and evenly.
Choosing the Right Serums for Your Skin Type
Selecting suitable serums based on individual skin concerns is crucial for achieving optimal results from microneedling. Different skin types have unique needs, and using the right serum can enhance the benefits of your treatment.
Serum Selection Tips:
- Sensitive Skin: Opt for serums containing calming ingredients like hyaluronic acid or niacinamide to reduce irritation and inflammation.
- Acne-Prone Skin: Look for formulations with niacinamide and zinc to help control oil production and soothe active breakouts.
- Dry Skin: Hydration is key. Hyaluronic acid and ceramide-rich serums can provide deep moisture and support the skin barrier.
- Aging Skin: Peptide-infused and EGF serums are excellent choices to promote collagen synthesis and improve firmness.
- Hyperpigmented Skin: Consider serums with epidermal growth factors (EGF) to help even out skin tone and reduce dark spots.
By tailoring your serum selection to your specific skin type, you can maximize the efficacy of your microneedling treatments. Always patch test new products before full application to ensure compatibility with your skin.
Applying Serums Effectively Post-Microneedling Treatment
Optimal serum application techniques can make a significant difference in the results you see after a microneedling session. To maximize absorption and minimize irritation, follow these guidelines:
- Layer serums from thinnest to thickest: Start with water-based or gel-like formulas such as hyaluronic acid, then move on to slightly thicker peptide or ceramide-rich options. Leave heavier, creamy serums or moisturizers for last.
- Pat, don’t rub: Use clean fingertips to gently pat each serum into your skin. Avoid rubbing or massaging, which can aggravate skin that’s already sensitive from microneedling.
- Allow each layer to absorb: Wait 30 seconds to a minute between layers so each serum penetrates fully before adding the next one.
- Focus on hydration and barrier repair: Hydrating and barrier-supportive serums should be prioritized immediately after treatment to support recovery.
This method ensures every ingredient is delivered deeply and evenly, taking advantage of the temporary increase in skin permeability created by microneedling.
Conclusion
Choosing the right serum for microneedling or dermarolling can significantly impact your results. Try out different combinations of hyaluronic acid, peptides, ceramides, EGF, and niacinamide + zinc to find what works best for your skin. Remember to always patch test new products and seek advice from a dermatologist or skincare professional if you’re uncertain about incorporating these serums into your routine. Personalization is crucial—your skin deserves specific care, especially after advanced treatments like microneedling.
Reference articles
https://diaminyaesthetics.com/blogs/news/best-serums-for-at-home-microneedling
https://facemedstore.com/best-serums-for-at-home-microneedling
https://www.healthline.com/health/beauty-skin-care/microneedling-at-home
https://eu.drpen.co/blogs/news/the-best-serums-to-use-with-microneedling
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About Bradceuticals : Thuy Myers is the founder of Bradceuticals which manufactures and distributes skin care and hair regrowth serums that use growth factors from human stem cells as the catalyst for regeneration. When she is not busy running the business and maintaining blogs, she is continuing her practice as a semiconductor engineer and occasionally teaches college engineering. In her free time, she enjoys the beach, working out at the gym and hanging out with her kiddo Brad.